It plays a regulatory role in poststroke kinematic learning and rehabilitation. The research progress of the role of BDNF in neural plasticity, neural protection, and neurogenesis may provide important information for the formulation of new poststroke rehabilitation strategies. When miR-210 is overexpressed, microvessel density and the number of neuronal progenitor cells in the brain of ischemic mice can be increased, thus improving the neurobehaviour of ischemic mice. However, miR-210 can regulate brain-derived neurotrophic factor (BDNF). MicroRNA is a class of small-molecule noncoding short-stranded RNA that regulates and influences the occurrence and development of diseases such as cancer and cardiovascular and cerebrovascular diseases by their target proteins. Therefore, we need some indicators to diagnose the disease and predict the prognosis, so that medical staff can carry out targeted and effective treatment according to the predicted situation.
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The number of cerebral infarction patients worldwide was 33 million in 2010, and it would increase to 77 million by 2030 according to epidemiological speculation. With the development of social aging, its incidence shows an upward trend. And most of acute stroke is acute cerebral infarction, which has become the main cause of global disability events. The incidence and mortality of cerebral infarction are much higher than those of other brain injury diseases.
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The patients usually have sudden onset and will show symptoms in a short time. IntroductionĬerebral infarction is a kind of brain injury caused by obstruction of blood supply in the brain. miR-210, miR-137, and miR-153 have a certain value in the diagnosis and prediction of 1-year death of acute cerebral infarction and may be potential diagnostic and predictive indicators. Pearson’s correlation analysis showed that the expression of miR-210 was positively correlated with that of miR-137, while miR-137 was negatively correlated with that of miR-153 and miR-210 was negatively correlated with that of miR-153. The ROC curve for predicting death showed that the area under curve of miR-210 was 0.786, that of miR-137 was 0.824, and that of miR-153 was 0.858. The 1-year survival of the low-expression group of miR-210 and miR-137 was significantly lower than that of the high-expression group, while the 1-year survival of the low-expression group of miR-153 was significantly higher than that of the high-expression group (all ). The ROC curve of diagnosis of acute cerebral infarction showed that the area under curve of miR-210 was 0.836, that of miR-137 was 0.843, and that of miR-153 was 0.842.
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Levels of miR-210 and miR-137 in the observation group were significantly lower than those in the control group, while levels of miR-153 in the observation group were significantly higher than those in the control group (all ). The correlation between miR-210, miR-137, and miR-153 in the serum of the observation group was analyzed by Pearson’s test. Receiver operating characteristic (ROC) curve was employed to analyze the diagnostic value and predictive value of miR-210, miR-137 and miR-153 death in patients. qRT-PCR was used to detect the expression of miR-210, miR-137, and miR-153 in the serum of each group. The patients were divided into the death and survival groups based on 1-year mortality of patients. Another 64 normal patients were selected as the control group. 76 patients with acute cerebral infarction treated in our hospital from April 2016 to October 2017 were enrolled as the observation group. To explore the expression levels of miR-210, miR-137, and miR-153 in patients with acute cerebral infarction.